Levetiracetam and psychosis.

We present the case of a 45-year old woman diagnosed of partial complex epilepsy from childhood that was stabilized with carbamazepine 400 mg/day over all the years. Due to the decrease in libido secondary to this drug, she began to have problems in her personal life so that her attending neurologist decided to switch her to levetiracetam 1500 mg/day. Two months after the change in anti-epileptic treatment, the patient developed an acute psychotic episode with affective symptoms, predominating irritability, with delusional ideas having megalomystic content and behavioral disorders secondary to auditory hallucinations. This clinical picture did not change even after the drug was withdrawn, as other previous studies have described. Therefore, at present, two years after the debut, she continues to require maintenance antipsychotic medication.